本文探索了钠离子慢失活(恢复)门对维持信息稳定传导的重要作用,它可以作为维持神经系统正常以及疾病状态下的自我保护机制。相较于基于硅材料构建的硬件系统,生物系统具有更多的不确定性,但其自身的可调节性也更具创造性。 参考文献1. Zang, Y., and Marder, E. (2021). Interactions among diameter, myelination, and the Na/K pump affect axonal resilience to high-frequency spiking. Proc. Natl. Acad. Sci. U S A 118, e2105795118. 10.1073/pnas.2105795118.2. Zang, Y., and Marder, E. (2023). Neuronal morphology enhances robustness to perturbations of channel densities. Proc. Natl. Acad. Sci. U S A 120, e2219049120.3. Zang, Y., Marder, E., and Marom, S. (2023). Sodium channel slow inactivation normalizes firing in axons with uneven conductance distributions. Curr. Biol. 33, 1-7. 10.1016/j.cub.2023.03.043.4. Hodgkin, A.L., and Huxley, A.F. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol 117, 500-544. 10.1113/jphysiol.1952.sp004764.5. O'Leary, T., Williams, A.H., Franci, A., and Marder, E. (2014). Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model. Neuron 82, 809-821. 10.1016/j.neuron.2014.04.002. 作者简介臧蕴亮博士毕业于浙江大学生物医学工程专业,先后师从国际计算神经学会前主席Erik De Schutter教授和美国科学院院士Eve Marder教授,在小脑智能与神经系统鲁棒性方面取得了一系列成果,代表性工作以一作发表在PNAS、Current Biology、Cell Reports、eLife和Journal of Neuroscience等神经科学领域旗舰期刊上。近期将加入天津大学医学工程与转化医学研究院担任英才教授,欢迎对神经科学以及类脑计算感兴趣的同学加入实验室。